GlutaredoxinV1, Main, Exploration, bibRecord, 000405

The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.

Identifieur interne : 000405 ( Main/Exploration ); précédent : 000404; suivant : 000406

The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.

Auteurs : Rie Ishikawa [Japon] ; Yosuke Amano [Japon] ; Masanori Kawakami [Japon] ; Mitsuhiro Sunohara [Japon] ; Kousuke Watanabe [Japon] ; Hidenori Kage [Japon] ; Nobuya Ohishi [Japon] ; Yutaka Yatomi [Japon] ; Jun Nakajima [Japon] ; Masashi Fukayama [Japon] ; Takahide Nagase [Japon] ; Daiya Takai [Japon]

Source :

Japanese journal of clinical oncology [ 1465-3621 ] ; 2016.

RBID : pubmed:26685324

Descripteurs français

English descriptors

KwdEn :
- Aged (MeSH), Biomarkers, Tumor (analysis), Carcinoma, Non-Small-Cell Lung (chemistry), Carcinoma, Non-Small-Cell Lung (pathology), Chimera (MeSH), Core Binding Factor Alpha 2 Subunit (analysis), Female (MeSH), Glutaredoxins (analysis), Humans (MeSH), Lung Neoplasms (chemistry), Lung Neoplasms (pathology), Male (MeSH), Middle Aged (MeSH), Neoplasm Recurrence, Local (MeSH), Neoplasm Staging (MeSH), Postoperative Period (MeSH), Predictive Value of Tests (MeSH), Prognosis (MeSH), Survival Analysis (MeSH).
MESH :
- chemical , analysis : Biomarkers, Tumor, Core Binding Factor Alpha 2 Subunit, Glutaredoxins.
- chemistry : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Aged, Chimera, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Postoperative Period, Predictive Value of Tests, Prognosis, Survival Analysis.

Abstract

Stage IA non-small-cell lung cancer cases have been recognized as having a low risk of relapse; however, occasionally, relapse may occur. To predict clinical outcome in Stage IA non-small-cell lung cancer patients, we searched for chimeric transcripts that can be used as biomarkers and identified a novel chimeric transcript, RUNX1-GLRX5, comprising RUNX1, a transcription factor, and GLRX5. This chimera was detected in approximately half of the investigated Stage IA non-small-cell lung cancer patients (44/104 cases, 42.3%). Although there was no significant difference in the overall survival rate between RUNX1-GLRX5-positive and -negative cases (P = 0.088), a significantly lower relapse rate was observed in the RUNX1-GLRX5-positive cases (P = 0.039), indicating that this chimera can be used as a biomarker for good prognosis in Stage IA patients. Detection of the RUNX1-GLRX5 chimeric transcript may therefore be useful for the determination of a postoperative treatment plan for Stage IA non-small-cell lung cancer patients.

DOI: 10.1093/jjco/hyv187
PubMed: 26685324
PubMed Central: PMC4731000

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Carcinoma, Non-Small-Cell Lung (chemistry)</term>
<term>Carcinoma, Non-Small-Cell Lung (pathology)</term>
<term>Chimera (MeSH)</term>
<term>Core Binding Factor Alpha 2 Subunit (analysis)</term>
<term>Female (MeSH)</term>
<term>Glutaredoxins (analysis)</term>
<term>Humans (MeSH)</term>
<term>Lung Neoplasms (chemistry)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Neoplasm Recurrence, Local (MeSH)</term>
<term>Neoplasm Staging (MeSH)</term>
<term>Postoperative Period (MeSH)</term>
<term>Predictive Value of Tests (MeSH)</term>
<term>Prognosis (MeSH)</term>
<term>Survival Analysis (MeSH)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de survie (MeSH)</term>
<term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term>
<term>Carcinome pulmonaire non à petites cellules (composition chimique)</term>
<term>Chimère (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Glutarédoxines (analyse)</term>
<term>Humains (MeSH)</term>
<term>Marqueurs biologiques tumoraux (analyse)</term>
<term>Mâle (MeSH)</term>
<term>Pronostic (MeSH)</term>
<term>Période postopératoire (MeSH)</term>
<term>Récidive tumorale locale (MeSH)</term>
<term>Sous-unité alpha 2 du facteur CBF (analyse)</term>
<term>Stadification tumorale (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (composition chimique)</term>
<term>Valeur prédictive des tests (MeSH)</term>
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<term>Core Binding Factor Alpha 2 Subunit</term>
<term>Glutaredoxins</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Glutarédoxines</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Sous-unité alpha 2 du facteur CBF</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term>
<term>Lung Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Chimera</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm Staging</term>
<term>Postoperative Period</term>
<term>Predictive Value of Tests</term>
<term>Prognosis</term>
<term>Survival Analysis</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Chimère</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Période postopératoire</term>
<term>Récidive tumorale locale</term>
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<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en">Stage IA non-small-cell lung cancer cases have been recognized as having a low risk of relapse; however, occasionally, relapse may occur. To predict clinical outcome in Stage IA non-small-cell lung cancer patients, we searched for chimeric transcripts that can be used as biomarkers and identified a novel chimeric transcript, RUNX1-GLRX5, comprising RUNX1, a transcription factor, and GLRX5. This chimera was detected in approximately half of the investigated Stage IA non-small-cell lung cancer patients (44/104 cases, 42.3%). Although there was no significant difference in the overall survival rate between RUNX1-GLRX5-positive and -negative cases (P = 0.088), a significantly lower relapse rate was observed in the RUNX1-GLRX5-positive cases (P = 0.039), indicating that this chimera can be used as a biomarker for good prognosis in Stage IA patients. Detection of the RUNX1-GLRX5 chimeric transcript may therefore be useful for the determination of a postoperative treatment plan for Stage IA non-small-cell lung cancer patients. </div>
</front>
</TEI>
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<DateCompleted><Year>2016</Year>
<Month>07</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-3621</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>46</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Japanese journal of clinical oncology</Title>
<ISOAbbreviation>Jpn J Clin Oncol</ISOAbbreviation>
</Journal>
<ArticleTitle>The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.</ArticleTitle>
<Pagination><MedlinePgn>185-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/jjco/hyv187</ELocationID>
<Abstract><AbstractText>Stage IA non-small-cell lung cancer cases have been recognized as having a low risk of relapse; however, occasionally, relapse may occur. To predict clinical outcome in Stage IA non-small-cell lung cancer patients, we searched for chimeric transcripts that can be used as biomarkers and identified a novel chimeric transcript, RUNX1-GLRX5, comprising RUNX1, a transcription factor, and GLRX5. This chimera was detected in approximately half of the investigated Stage IA non-small-cell lung cancer patients (44/104 cases, 42.3%). Although there was no significant difference in the overall survival rate between RUNX1-GLRX5-positive and -negative cases (P = 0.088), a significantly lower relapse rate was observed in the RUNX1-GLRX5-positive cases (P = 0.039), indicating that this chimera can be used as a biomarker for good prognosis in Stage IA patients. Detection of the RUNX1-GLRX5 chimeric transcript may therefore be useful for the determination of a postoperative treatment plan for Stage IA non-small-cell lung cancer patients. </AbstractText>
<CopyrightInformation>© The Author 2015. Published by Oxford University Press.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ishikawa</LastName>
<ForeName>Rie</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Respiratory Medicine, The University of Tokyo Hospital, Tokyo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amano</LastName>
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   |texte=   The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.
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The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.

The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.

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